在整体甲状腺切除术期间,对手术内副甲状腺激素测量的个体方法
Michael Vaiman1, Yuval Mizrakli1, Ahmed Taha1
1Department of Otolaryngology-Head and Neck Surgery, Shamir (Assaf Harofeh) Medical Center, Zerifin, Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
American journal of otolaryngology
|December 19, 2023
概括
在甲状腺切除后1-2分钟测量副甲状腺激素 (PTH) 水平可以准确预测手术后的低血症. 这使得大多数患者能够提前出院,避免不必要的血液测试.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 神经外科 神经外科
背景情况:
- 低血是甲状腺切除术后经常出现的并发症.
- 在手术期间对甲状腺类激素 (PTH) 水平的测量已经确立,但需要优化.
- 及时的PTH评估对于治疗甲状腺切除术后并发症至关重要.
研究的目的:
- 为了评估甲状腺腺体切除后,手术内立即进行副甲状腺激素 (PTH) 水平测试的疗效.
- 为了确定PTH测定时间是否可以优化,以提高预测低血症的准确性.
- 评估PTH水平可以在甲状腺切除术后不久可靠地测量这一假设.
主要方法:
- 回顾性队列研究,涉及经过全甲状腺切除术的患者.
- 在切口时和甲状腺切除后立即测量了手术内PTH水平.
- 手术后连续监测血液中总水平,每天监测两次.
主要成果:
- 摘除腺体后PTH的70%降低预测了术后低血症,具有100%的灵敏度和82.9%的特异性.
- 患有≥50%PTH降低的患者是正常血症,并提前出院.
- 确定患者的PTH降低≥70%,需要监测,防止永久性低血症.
结论:
- 术内PTH测量应在甲状腺切除后1-2分钟内进行,而不是固定间隔.
- 识别有风险的患者可以让大多数人提前出院,放弃了常规的术后测试.
- 优化的手术内PTH测试可以改善甲状腺切除术后的患者管理和资源利用.
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