塑造大脑:皮层结构和折叠的出现
Shyam K Akula1, David Exposito-Alonso1, Christopher A Walsh1
1Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA; Allen Discovery Center for Human Brain Evolution, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
Developmental cell
|December 19, 2023
概括
人类大脑皮层负责高级认知,在发育过程中经历了复杂的折叠. 最近的研究强调了分子,细胞和机械因素,以及祖细胞,推动了这一关键的化过程.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 遗传学 遗传学 是一个
背景情况:
- 人类大脑皮层是高级认知功能的关键.
- 了解它的发育,细胞类型和组织正在迅速推进.
- 皮层折叠 (化) 是人类大脑进化和复杂性的标志.
研究的目的:
- 审查了解调节大脑皮层折叠的分子,细胞和机械因素的近期进展.
- 突出皮层前代在化和大脑扩张中的作用.
- 将发育机制与神经发育障碍联系起来.
主要方法:
- 评论最近的科学文献.
- 整合了人类遗传学研究的发现.
- 在旋脑 (皮层折叠) 物种中的实验建模.
主要成果:
- 皮层原生细胞在化和进化扩张中发挥着中心作用.
- 分子和细胞过程,以及机械力,是皮层折叠的关键调节者.
- 进步为皮质结构和组织的出现提供了洞察力.
结论:
- 了解皮层发育对于破译大脑进化至关重要.
- 这种知识对于理解涉及皮质形的神经发育障碍的起源至关重要.
- 未来的研究方向将集中在原始细胞的作用和调控机制上.
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