在土耳其的儿科脏病实践中使用rituximab: TRTXX
Ahmet Ünal1, Emre Leventoğlu2, Sevcan A Bakkaloğlu2
1Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey.
Nephrology (Carlton, Vic.)
|December 19, 2023
概括
土耳其的儿科科医生通常使用rituximab (RTX) 治疗脏综合征和其他脏疾病. 然而,治疗前检测和患者监测的做法各不相同,这凸显了对标准化RTX指导方针的需求.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 利图西马布 (RTX) 是一种针对CD20的单克隆抗体,用于儿科脏病学.
- 目前使用的RTX缺乏标准化的协议,导致实践变化.
研究的目的:
- 调查土耳其儿科脏病学家当前的RTX使用模式.
- 确定RTX的常见指示,预处理方案和监测实践.
主要方法:
- 全国范围,多中心,回顾性队列研究.
- 在线调查问卷分发给土耳其所有儿科脏病中心.
- 收集了关于患者数量,适应症和RTX制剂的数据.
主要成果:
- RTX最常用于类固醇敏感性脏综合征 (SSNS),其次是类固醇耐药性脏综合征 (SRNS),抗体介导排斥 (ABMR),系统性红斑狼 (SLE) 和抗中性粒细胞质抗体相关血管炎 (AAV).
- 虽然剂量是标准化的,但在暴露前测试和患者监测方面存在显著的异质性.
- 医生报告RTX相关的过敏和传染性副作用的发生率很高.
结论:
- 显然需要基于证据的指导方针.
- 该指南应涵盖儿科脏病患者的RTX指示,剂量和输注前/后管理.
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