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精确的微生物干预可以改善社会行为,但不能改善自闭症严重程度:一项试点双盲随机化安慰剂控制试验

Luigi Mazzone¹, Sean W Dooling², Elisabetta Volpe³

¹Child Neurology and Psychiatry Unit, Department of Neurosciences, Policlinico Tor Vergata Foundation Hospital, Viale Oxford 81, 00133 Rome, Italy; Systems Medicine Department, University of Rome Tor Vergata, Montpellier Street 1, 00133 Rome, Italy.

Cell host & microbe

|December 19, 2023

概括

这项研究发现,Lactobacillus reuteri (L. reuteri) 在患有自闭症谱系障碍 (ASD) 的儿童中改善了社会功能. 虽然不影响整体自闭症严重程度,但L. reuteri为新的ASD治疗策略提供了一个有希望的途径.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
儿科儿科儿科

背景情况:

自闭症谱系障碍 (ASD) 在社交沟通和限制行为方面存在挑战,有效治疗方法有限.
临床前研究表明,Lactobacillus reuteri (L. reuteri) 可能可以改善ASD模型中观察到的社会缺陷.

研究的目的:

研究一种特定的L. reuteri组合 (菌株ATCC-PTA-6475和DSM-17938) 在改善ASD儿童的社会功能方面的有效性.
评估L. reuteri对整体自闭症严重程度,重复性行为,微生物组合和免疫特征的影响.

主要方法:

进行了一项双盲,随机,安慰剂对照试验,涉及被诊断为ASD的儿童.
参与者接受了L. reuteri组合或安慰剂.
临床前研究使用了ASD的小鼠模型来评估菌株特异性的影响.

主要成果:

在ASD儿童中,L. reuteri组合显著改善了多项措施的社会功能.
在整体自闭症严重程度,限制性/重复性行为,微生物组组成或免疫特征方面没有发现显著变化.
在临床前的小鼠模型中,L. reuteri菌株ATCC-PTA-6475,但不是DSM-17938,扭转了社会赤字.

结论:

乳杆菌reuteri显示出作为治疗剂的潜力,用于增强ASD儿童的社会行为.
需要进一步的研究,包括更大规模的试验,重点关注菌株特异性影响,以证实这些发现.

关键词:

自闭症谱系障碍自闭症谱系障碍临床试验临床试验临床试验临床试验临床试验肠道-微生物群-大脑轴益生菌是一种益生菌.社会行为社会行为.

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