多站点化决定了选择性的E2-E3配对,正如Ubc8/UBE2H-GID/CTLH组件所揭示的那样

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Updated: Jul 8, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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Jakub Chrustowicz1, Dawafuti Sherpa1, Jerry Li2

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

Molecular cell
|December 19, 2023
PubMed
概括

酸化指导了E3-E2酶在无处不在中的合作伙伴关系. 这项研究揭示了Ubc8/UBE2H E2酶的多站点酸化如何将它们结到GID/CTLH E3酶上,确保了特定的无处不在.

关键词:
在CK2中,CK2是CK2.复杂的CTLH是一个复杂的CTLH.E2 泛素结合酶的结合酶.E3 无处不在的合酶GID复合体是一个复杂的GID.这就是UBE2H.在UBC8中,UBC8是UBC8.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.酸化的方法是:光化.在任何地方都是无处不在的.

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