双甲状腺视神经病变中的眼外肌肉扩大
Khizar Rana1, Devanshu Garg1, Lee Shien S Yong1
1Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia; Department of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
|December 19, 2023
概括
甲状腺眼病 (TED) 患有甲状腺视神经病变 (DON) 的患者表现出显著增加的眼外肌肉体积. 上斜肌扩大是关键指标,这表明它是DON的新标志物.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 甲状腺眼部疾病 (TED) 是一种影响轨道的自身免疫性疾病.
- 甲状腺视神经病变 (DON) 是TED的一个视力威胁的并发症.
- 准确识别DON对于及时干预至关重要.
研究的目的:
- 为了比较TED患者的眼外肌肉体积,有和没有DON.
- 为了确定与DON相关的特定肌肉变化.
- 评估肌肉扩大的潜力作为DON的标志物.
主要方法:
- 来自TED患者的200个轨道的回顾性队列研究.
- 计算机断层扫描 (CT) 扫描被用来评估轨道结构.
- 手动对眼外肌肉进行细分,以计算体积.
主要成果:
- 中间直肠,侧直肠,上部肌肉群,下部直肠和上部斜体体积在DON患者中显著增加 (p < 0.01).
- 下斜肌体积在各组之间没有显著差异 (p = 0.19).
- 上斜肌扩大显示了与DON的最高关联 (或每100毫米3增加1.58).
结论:
- 眼外肌肉扩大,特别是上斜部,是DON的重要发现.
- 上斜肌扩大可能成为预测TED患者DON的新型成像生物标志物.
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