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[从葡萄酒加工的Corni Fructus中获得的两种新型烯胺]

Jing Wang1, Jun Chi1, Pei Wang1

  • 1Henan University of Chinese Medicine Zhengzhou 450046, China Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Henan University of Chinese Medicine Zhengzhou 450046, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
|December 19, 2023
PubMed
概括

来自Corni Fructus的两种新化合物表现出强大的抗氧化和细胞保护性质. 这些发现突出了天然化合物的治疗潜力,可以对抗氧化应激和细胞损伤.

关键词:
生物活动是生物活动.化学成分 化学成分 化学成分烯烯醇 (Phenyl Propanols) 是一种烯烯的化合物.在葡萄酒加工中加工的Corni Fructus.

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科学领域:

  • 植物化学 植物化学
  • 自然产品化学 自然产品化学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 科尔尼果实是一种传统的药用植物,以其丰富的植物化学成分而闻名.
  • 葡萄酒加工可能会改变生物活性化合物的提取和成分.
  • 了解加工的Corni Fructus的化学成分和生物活性对于其药用应用至关重要.

研究的目的:

  • 从葡萄酒加工的Corni Fructus的水性提取物中分离和识别化学成分.
  • 评估分离化合物的抗氧化和细胞保护活性.

主要方法:

  • 使用各种色谱技术分离化合物,包括凝,ODS,Sephadex LH-20和准备HPLC.
  • 使用HR-ESI-MS,UV,IR,NMR和ECD等综合光谱方法进行结构阐明.
  • 通过DPPH自由基清除试验和对NRK-52E细胞中过氧化诱导的氧化损伤的保护来评估生物活动.

主要成果:

  • 六种化合物被分离和鉴定出来:皮诺雷西诺酸B (1),角质酸A (2), (+) - 隔离基雷西诺酸-9'-O-β-葡萄糖酸 (3), (-) - 隔离基雷西诺酸3α-O-β-D-葡萄糖酸 (4), (7R,8S) - 二二二二尼醇9-O-β-D-葡萄糖酸 (5),和 (-) - 二次隔离基雷西诺酸-9'-O-β-D-葡萄糖酸 (6).
  • 化合物1 (pinoresinoside B) 和2 (cornusgallicacid A) 被确定为新的化合物.
  • 化合物2和6表现出显著的DPPH自由基清除活性,EC50值分别为4.18±1.96 μmol·L-1和21.45±1.19 μmol·L-1.
  • 化合物1和2对NRK-52E细胞的H2O2诱导氧化损伤表现出剂量依赖的保护,而化合物2的细胞存活率为96.09%±1.77%在100μmol·L−1.1.

结论:

  • 该研究成功地分离和表征了葡萄酒加工的Corni Fructus中的六种化合物,包括两种新型化合物.
  • 玉米酸A (2) 和 (-) - 干燥分离剂醇-9'-O-β-D-葡萄皮化物 (6) 具有显著的抗氧化特性.
  • 皮诺雷西诺酸B (1) 和角酸A (2) 显示出对抗氧化应激的显著细胞保护作用,表明它们的治疗潜力.