[来自Hedyotis scandens全草的化学成分]
Yu-Jun Wang1, Ju-Min Huang1, Chun Wen1
1Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China.
概括
这项研究从Hedyotis scandens中确定了13种化学化合物,包括两种新的酸. 一些化合物显示出对Mycobacterium smegmatis的抑制作用.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
背景情况:
- Hedyotis scandens是一种具有传统药用用途的植物.
- 研究其化学成分可以揭示新的生物活性化合物.
研究的目的:
- 从Hedyotis scandens的水提取物中分离和识别化学成分.
- 评估分离化合物的生物活性.
主要方法:
- 凝,ODS和MCI柱状染色学.
- 准备性高性能液体染色学 (HPLC). 准备性高性能液体染色学.
- 使用NMR和HR-ESI-MS阐明结构.
主要成果:
- 隔离和鉴定了13种化合物,包括两种新的酸 (1和2).
- 第一次从这个属中报告了3-5,8-11和13的化合物.
- 6,7和12的化合物首次从H.scandens中分离出来.
- 化合物1和10表现出对Mycobacterium smegmatis的抑制活性.
结论:
- 对Hedyotis scandens的化学研究产生了13种化合物,扩大了对其植物化学特征的了解.
- 鉴定了新的酸和以前未在该属中报告的化合物,有助于自然产品化学.
- 对Mycobacterium smegmatis的观察到的抑制活性突出显示了Hedyotis scandens成分的潜力,作为抗菌菌药物发现的领先因素.
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