在新生儿中药物分发中的抗生素度的准确性:基于实验室的研究
Li-Yuan Zheng1,2, Wei-Ping Gu2, Na Liang3
1Department of Clinical Pharmacy, Institute of Clinical Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
BMJ paediatrics open
|December 19, 2023
概括
方法B,双体积稀释,被证明是最准确的给新生儿输入静脉注射抗生素. 这种方法确保了对关键新生儿感染的精确剂量,特别是在较小的药物强度下.
科学领域:
- 新生儿药理学和治疗学
- 药物复合和制剂的准确性 药物复合和制剂的准确性
- 在脆弱人群中使用抗生素剂量.
背景情况:
- 准确的抗菌剂量对治疗新生儿感染至关重要.
- 实际抗生素剂量的变化可能会影响新生儿的治疗疗效.
- 处方过程可能会引入影响最终药物度的错误.
研究的目的:
- 评估影响新生儿处方过程中静脉注射抗生素实际剂量的因素.
- 为了比较常见新生儿抗生素三种不同的稀释方法的准确性.
主要方法:
- 三种静脉注射的抗生素 (美罗,塞福拉/苏尔巴克坦,皮佩拉西林/塔扎巴克坦) 在两种强度下进行了测试.
- 评估了三种稀释方法 (方法A:单次稀释;方法B:双体积稀释;方法C:双稀释).
- 高性能液体色谱测量了药物度,与相对误差 (RE) 评估准备准确性.
主要成果:
- 与A方法相比,B方法在所有测试的抗生素和强度中表现出更高的准确性.
- 在单次和双次稀释 (方法A与C) 之间没有观察到RE的显著差异,除了低强度的美罗.
- 方法B在使用较小的药物强度时,可以获得更高的准备精度的美罗和皮佩拉西林/塔扎巴克坦.
结论:
- 推B方法用于新生儿药物分发,因为其高准确性和操作简单性.
- 强度较小的抗生素特别适合B方法,提高了制备的准确性.
- 优化配药方法对于确保新生儿抗菌疗法的治疗疗效至关重要.
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