咖啡因和蓝色丰富光对认知表现和脑电图效果的有效性与太空飞行机器人模拟中的警觉相关
Erin E Flynn-Evans1,2,3, Melanie Rueger1,2, Andrew M Liu4
1Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, 02115, Boston, MA, USA.
NPJ microgravity
|December 19, 2023
概括
低剂量的咖啡因和蓝色丰富的光线可以在模拟太空飞行期间提高警觉. 然而,咖啡因可能会扰乱随后的睡眠,而光线可以减少嗜睡指标.
科学领域:
- 太空医学 太空医学
- 人类因素工程 人类因素工程
- 睡眠科学 睡眠科学
背景情况:
- 由于睡眠丧失和昼夜调节失调而导致的认知障碍,在高压力的工作中,特别是太空飞行中,存在风险.
- 咖啡因和蓝色丰富的白光是潜在的对策,可在国际空间站使用.
研究的目的:
- 评估低剂量咖啡因和蓝色丰富的白光的有效性,单独和组合,作为对抗睡眠丧失和昼夜失调的对策.
- 在模拟太空飞行环境中评估它们对警觉,表现和睡眠质量的影响.
主要方法:
- 一个随机的,安慰剂控制的,交叉试验,涉及16名参与者模拟太空飞行睡眠和清醒转移.
- 低剂量咖啡因 (0.3 mg/kg/h) 和适度的蓝色丰富光 (~90 lux) 的使用.
- 在夜间工作和睡眠期间评估主观和客观的警觉,表现和脑电图 (EEG).
主要成果:
- 慢性低剂量咖啡因在睡眠丧失和昼夜调整不当期间改善了警觉和表现,但破坏了随后的睡眠.
- 蓝色丰富光 (90卢克斯) 降低了theta和delta区域的EEG功率,与嗜睡有关.
- 组合使用没有明确详细说明,但含义表明潜在的好处与警告.
结论:
- 低剂量咖啡因可以提高轮班工人和睡眠不足的宇航员的警觉性和表现.
- 富含蓝色的白光可能有助于缓解嗜睡.
- 需要进一步的研究来优化联合使用和管理潜在的睡眠障碍.
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