饥荒会导致多少精神分裂症?
Cormac Ó Gráda1, Chihua Li2, L H Lumey3
1University College Dublin, Dublin, Ireland. cormac.ograda@ucd.ie.
在子宫中的饥荒暴露与精神分裂症有关,但其对人类成本的长期影响是温和的. 这项研究量化了对饥荒死亡人数的最小影响,揭示了对整体死亡率的小贡献.
科学领域:
- 流行病学 流行病学
- 发育神经科学的发展神经科学.
- 公共卫生 公共卫生
背景情况:
- 饥饿已经被用作自然实验来研究胎儿营养冲击的长期影响.
- 以前的研究表明,胎儿暴露与发展精神分裂症的几率增加之间存在强烈的关联.
研究的目的:
- 调查精神分裂症的胎儿起源对饥荒的更广泛的人类成本的影响.
- 量化胎儿暴露于营养冲击对精神分裂症发病率相对于整体饥荒死亡率的影响.
主要方法:
- 分析涉及历史饥荒的案例研究.
- 与胎儿暴露相关的精神分裂症发病率与总饥荒死亡人数的比较.
主要成果:
- 胎儿起源的精神分裂症对饥荒的人类总体成本的影响是温和的.
- 归因于胎儿暴露的精神分裂症病例在选定的案例研究中占相关饥荒死亡人数的不到1%.
结论:
- 虽然饥荒期间胎儿暴露与精神分裂症有关,但其对饥荒总死亡负担的贡献很小.
- 在精神分裂症发病率方面,饥荒对人类的长期成本被直接死亡率所掩盖.
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