体重循环与结直肠癌风险之间的关联:一项前性队列研究
Suryun Kim1, Dong Hoon Lee2,3, Edward L Giovannucci3,4
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
British journal of cancer
|December 19, 2023
概括
适度体重循环,定义为减肥3倍或更多,可能会降低结肠直肠癌的风险,独立于体重指数 (BMI). 这一发现表明,特定体重循环模式与癌症预防之间存在潜在联系.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 代谢健康 代谢健康
背景情况:
- 重量循环,以重复的有意减肥和无意增加体重为特征,是常见的.
- 体重循环频率/幅度与结直肠癌 (CRC) 风险之间的独立关联尚未得到充分理解.
- 现有研究尚未澄清体重循环是否影响超出整体体重指数 (BMI) 的CRC风险.
研究的目的:
- 调查体重循环模式与结直肠癌风险之间的关系.
- 要确定这种关联是否独立于体重指数 (BMI).
主要方法:
- 利用了来自两个大型前性队列研究的数据:护士健康研究I和卫生专业人员随访研究.
- 在85,562名参与者身上进行了长达22年的跟踪 (1992-2014).
- 通过基线问卷评估重量循环频率和大小;使用Cox比例危险模型分析CRC风险.
主要成果:
- 确定了1626例结直肠癌病例.
- 适度体重循环 (≥3个≥2.3-4.4公斤的故意体重减轻事件) 与降低CRC风险 (HR=0.82,95%CI 0.69-0.97) 相关,在调整了混因素后,包括达到的BMI.
- 对于轻度或重度体重循环模式,没有发现显著的关联.
结论:
- 适度体重循环表现出与结直肠癌风险降低的相关性,独立于BMI.
- 需要进一步的研究来复制这些发现并探索潜在的生物机制.
- 这项研究表明,体重循环行为与癌症风险之间存在微妙的关系.
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