相关实验视频
Updated: Jul 8, 2025

08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
6.4K
产前和新生儿暴露于SARS-CoV-2和儿童发育:系统性审查和元分析
Rebecca Jackson1, Kathryn Woodward1, Meg Ireland1
1Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Pediatric research
|December 19, 2023
概括
有限的证据表明,在新生儿期暴露于SARS-CoV-2 (导致COVID-19的病毒) 的婴儿中,发育迟缓的风险没有增加. 需要进行更大规模的研究来证实这些研究结果,无论是术后还是早产婴儿.
科学领域:
- 儿科 儿科 儿科
- 新生儿科学 新生儿科学
- 发展心理学 发展心理学
背景情况:
- 随着COVID-19大流行,人们对SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 感染对婴儿发育的潜在影响感到担忧.
- 了解产前和新生儿暴露的影响对于监测婴儿健康和发育至关重要.
研究的目的:
- 系统地审查在怀孕期间和新生儿期接触SARS-CoV-2对早产和早产婴儿发育结果的影响.
- 综合当前关于新生儿SARS-CoV-2暴露和婴儿发育轨迹之间的关联的证据.
主要方法:
- 在多个数据库 (Embase,Emcare,MEDLINE,PsycINFO,Web of Science) 和灰色文献中进行了系统的文献搜索,直到2023年5月.
- 研究包括已确认暴露于SARS-CoV-2的婴儿,一个未暴露的对照组,并报告了长达两岁的发育结果.
- 对现有数据进行了元分析,重点关注3至11个月的婴儿发育迟缓.
主要成果:
- 包括828名查者中的四项研究,涉及815名婴儿 (306名暴露,509名未暴露).
- 在按期出生的婴儿中,没有发现沟通,毛细运动,精细运动,解决问题或个人社会发展方面的延迟风险增加.
- 对早产婴儿的数据不足以进行有意义的比较,因为暴露和对照组的样本大小非常小.
结论:
- 目前关于产前或新生儿接触SARS-CoV-2对婴儿发育的影响的证据有限且不一致.
- 稀少的数据表明,在12个月以下的婴儿中,与不良发育结果没有一致的关联.
- 需要更大的长期随访队伍来确定SARS-CoV-2暴露对儿童发育的潜在持久影响.
相关概念视频
Development of Immunocompetence
312
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
312
Socioemotional Development during Infancy
55
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
55
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
293
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
293
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K

