慢性高的压力激素水平调节不良精子长非编码RNA及其胚胎微注射改变了发育和情感行为
L B Hoffmann1,2, B Li2, Q Zhao3
1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Molecular psychiatry
|December 19, 2023
概括
父亲的压力可以改变精子长非编码RNA (lncRNAs),影响后代的发育和行为. 这些lncRNAs在表观遗传中发挥作用,影响大脑功能和情感障碍.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
背景情况:
- 精子RNA与父亲的表观遗传有关.
- 以前对精子长非编码RNA (lncRNAs) 的研究缺乏关于它们在后代表型中的作用的确证据.
- 父亲压力对精子 lncRNAs 和随后的遗传的影响需要进一步研究.
研究的目的:
- 研究精子长非编码RNAs (lncRNAs) 在父亲表观遗传中的作用.
- 为了确定父亲对皮质的暴露是否会改变精子lncRNA的表达.
- 评估微注射精子lncRNAs对后代发育和行为的影响.
主要方法:
- 使用了父亲的皮质激素暴露模型.
- 使用CaptureSeq进行精子 lncRNA表达的敏感评估.
- 在受精卵细胞中进行精子 lncRNAs 的微注射.
主要成果:
- 父亲对皮质类固醇的暴露导致精子中cRNA的表达失调,包括循环RNA和可转移元素的转录.
- 生物信息分析表明,这些lncRNAs在调节大脑发育和功能方面可能发挥作用.
- 从注射调制lncRNA群体的卵细胞中产生的后代体重较低,焦虑和情感行为发生变化.
结论:
- 精子长非编码RNAs (lncRNAs) 参与了父亲的表观遗传.
- lncRNAs可以调节后代的发育,大脑功能和行为.
- 这项研究为有关情绪障碍的lncRNA介导遗传提供了新的见解.
更多相关视频
相关概念视频
Spermatogenesis
102.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.5K
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Stress and Mental Health
159
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
159
Hypothalamic-Pituitary Axis
60.2K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.2K
Human Genetics
583
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
583
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31


