在叶中,thalamic亚区域的形态和代谢不对称性可以预测认知功能
Hsin Tung1,2,3,4, Shih-Chuan Tsai5,6, Pu-Rong Huang5
1Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Scientific reports
|December 19, 2023
概括
叶 (TLE) 涉及不对称的乳头体积和代谢变化. 在TLE患者中,在逆侧乳头亚区域中保持代谢活动对于保持处理速度至关重要.
科学领域:
- 神经成像是一种神经成像.
- 的研究研究.
- 认知神经科学 认知神经科学
背景情况:
- 叶 (TLE) 是一种常见的神经疾病.
- Thalamic 结构和功能变化与 TLE 有关.
- thalamic亚区域不对称性在TLE相关认知缺陷中的作用需要进一步阐明.
研究的目的:
- 通过对TLE患者的形态和代谢成像来研究thalamic亚区域的不对称变化.
- 确定这些不对称的胸膜变化与认知功能,特别是处理速度之间的关系.
主要方法:
- 对24名左TLE和15名右TLE患者的回顾性分析.
- 使用磁共振成像 (MRI) 的六个thalamic亚核的细分.
- 将MRI数据与正子发射断层扫描 (PET) 共同记录,以计算不对称的体积指数和规范化标准吸收值比率 (SUVR).
主要成果:
- 与体积损失相比,ipsilateral thalamic亚核显示SUVR显著下降.
- 后部和中部亚核在左TLE和右TLE均表现出持续较低的SUVR.
- 处理速度与代谢不对称性最强烈相关,显示基于TLE横向性的差异性相关性.
- 的持续时间与特定的thalamic亚区域的体积和代谢不对称性有负相关.
结论:
- 在thalamic亚区域的代谢变化比TLE的体积变化更为突出.
- 在相对侧面的胸膜子区域中保持代谢活动对于保持处理速度至关重要.
- 左TLE患者在后部亚核中显示出体积和代谢下降,而右TLE患者相对保留了ipsilateral thalamic体积.
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