基因表达概况和蛋白质-蛋白质网络分析揭示了预后枢纽生物标志物,这些生物标志物与2型糖尿病患者的癌症风险有关
Harshita Kasera1, Rajveer Singh Shekhawat1, Pankaj Yadav2
1Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, NH 62, Nagaur Road, Karwar, Jodhpur, Rajasthan, 342037, India.
Scientific reports
|December 19, 2023
概括
这项研究揭示了2型糖尿病 (T2DM) 与胰腺,肝脏和乳腺癌等常见癌症之间的共同遗传标记. 这些发现可能有助于预测T2DM患者的癌症风险.
科学领域:
- 基因组学就是基因组学.
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2DM) 和各种癌症对全球健康构成重大挑战.
- 流行病学数据表明T2DM患者的癌症风险增加,但潜在的遗传联系仍未得到充分研究.
研究的目的:
- 用计算分析来识别T2DM和常见癌症之间共享的差异表达基因 (DEGs).
- 探索T2DM与癌症同时发生的功能和分子途径.
- 发现潜在的基因标记,用于预测T2DM个体的癌症发病.
主要方法:
- 利用了来自T2DM外围血液单核细胞和来自Gene Expression Omnibus (GEO) 数据库的癌症患者的基因表达数据.
- 进行了差异基因表达分析,以确定T2DM中常见的DEG与胰腺癌 (PC),肝癌 (LC) 和乳腺癌 (BC) 相比.
- 进行了功能和通路丰富分析,并为顶级DEGs构建了蛋白质-蛋白质相互作用网络.
主要成果:
- 在T2DM和PC,LC和BC之间确定了共享的DEG.
- 功能性丰富分析涉及关键途径,包括细胞周期,免疫反应,细胞形态发生,基因表达和新陈代谢.
- 网络分析揭示了关键的枢纽基因:T2DM与PC中的7个,T2DM与LC中的6个,T2DM与BC中的5个.
结论:
- 这项研究强调了T2DM和常见癌症之间的共同遗传基础.
- 已识别的生物途径为将T2DM与癌症发展联系在一起的分子机制提供了洞察力.
- 发现的遗传标记可以作为T2DM患者PC,LC和BC风险的预测指标.
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