改善治疗耐药精神分裂症的结果:认知补救疗法的影响
Francesca Martini1, Marco Spangaro2, Margherita Bechi1
1Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.
European archives of psychiatry and clinical neuroscience
|December 19, 2023
概括
认知补救疗法 (CRT) 有效地改善了治疗耐药精神分裂症 (TRS) 患者的认知功能,缩小了与非TRS患者的差距. 早期实施CRT对于管理精神分裂症认知衰退至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 耐治疗精神分裂症 (TRS) 与严重的精神病理,神经生物学障碍和认知缺陷有关,特别是在语言能力方面.
- 认知障碍对精神分裂症患者的功能结果和生活质量产生重大影响.
- 认知补救疗法 (CRT) 是认知功能障碍的主要治疗方法,但其在TRS中的有效性需要进一步调查.
研究的目的:
- 将精神分裂症患者的CRT结果进行比较,分为TRS和非TRS组.
- 调查CRT是否可以弥合TRS和非TRS患者之间的认知表现差距.
主要方法:
- 150名精神分裂症患者的样本被分为TRS和非TRS组.
- 神经认知在基线和CRT后使用精神分裂症认知简要评估 (BACS) 和威斯康星卡排序测试 (WCST) 进行评估.
- 重复测量ANCOVA被用来分析集团内部和集团间的差异.
主要成果:
- 与非TRS患者相比,TRS患者在BACS-口头记忆和WCST-执行功能方面表现出更大的基线损伤.
- 在CRT后,TRS和非TRS组都显示出显著的认知改善.
- 在CRT后,TRS和非TRS组之间没有观察到显著的认知差异.
结论:
- 对于TRS患者来说,CRT是一种有价值的干预措施,能够改善认知功能并减少治疗反应组之间的认知差距.
- 建议早期将CRT与药物治疗结合起来,以减轻精神分裂症的认知和功能负担,特别是在TRS中.
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