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皮科比纳病毒在新热带地区自由活动的哺乳动物中的循环
Ezequiel Vanderhoeven1,2, Roberta Paresque3, Iago Mello3
1Instituto de Biología Subtropical, CONICET-Universidad Nacional de Misiones (UNaM), Puerto Iguazú, Misiones, Argentina. ezequiel_av@msn.com.
Veterinary research communications
|December 19, 2023
概括
皮科比纳病毒 (PBV) 在大西洋森林的自由生活动物中广泛传播,感染了各种物种. 这项研究表明,PBV可以在动物和人类之间传播,突出了潜在的跨物种感染风险.
科学领域:
- 病毒学 病毒学
- 生态生态学 生态生态学
- 基因组学就是基因组学.
背景情况:
- 皮科比纳病毒 (PBV) 是非包裹的,双链RNA病毒,具有双分割的基因组.
- PBV 呈现出高基因组异质性,并感染多种脊椎动物宿主,包括人类.
研究的目的:
- 调查巴西和阿根廷大西洋森林内自由生活的动物中PBV的循环和遗传多样性.
- 了解PBV在这个生态系统中的潜在传播途径和宿主病毒相互作用.
主要方法:
- 使用RT-PCR对各种自由生活动物 (虎,鹿,,动物,有袋动物) 的便样本进行分析.
- 测序阳性安普利康和随后的遗传学分析以确定病毒关系.
主要成果:
- 在133个便样本中,44个 (33.08%) 检测出PBV阳性.
- 测序和遗传学分析揭示了来自两国的PBV菌株,分组为基因组I,但没有基于宿主物种或地理来源的独特集群.
- 检测到的PBV菌株显示保存的核酸块,不论宿主物种.
结论:
- 在大西洋森林中,PBV在自由生活的动物中普遍存在,感染了广泛的物种.
- 这些发现支持了动物和人类之间PBV传播的假设,表明病毒进化中的潜在交叉事件.
- 这项研究提供了第一次了解大西洋森林中自由生活的动物中的PBV,强调了对物种间传播的进一步研究的需要.
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