氧化的迷幻度降低了前端对象和体运动皮质网络中的功能差异化
Rui Dai1,2,3, Zirui Huang4,5,6,7, Tony E Larkin1,8
1Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Communications biology
|December 19, 2023
概括
氧化,也称为笑气,减少大脑的功能差异化,类似于经典的迷幻药. 这种大脑活动的变化与迷幻体验的强度相关.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
背景情况:
- 氧化具有很长的使用历史和已知的心理影响.
- 对其迷幻体验的神经生物学研究是有限的.
研究的目的:
- 为了研究氧化的迷幻效应的神经生物学基础.
- 检查大脑功能几何和时间动态的变化.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 在35%的氧化施用前和施用期间收集了数据.
- 分析包括功能几何学的皮质梯度和时间动态的协同激活模式.
主要成果:
- 氧化降低了前端对象和体运动网络的功能差异化.
- 功能差异化降低与主观迷幻体验相反相关.
- 大脑的效果与经典迷幻药的效果相似.
结论:
- 氧化会改变大脑的功能几何和时间动态.
- 这些变化与药物的精神活性和迷幻效应有关.
- 研究结果表明,氧化和古典迷幻药之间存在共同的神经生物学机制.
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