尼普利林的表达增加与孕前炎的炎症有关
Sara Atta1, Rehab Mekky2, Mostafa Ibrahim3
1Medical Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Reproductive sciences (Thousand Oaks, Calif.)
|December 20, 2023
概括
尼普里林素 (NEP) 度与产前症 (PE) 的炎症和严重程度相关. 这表明NEP可以作为诊断和预测PE结果的生物标志物.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 孕前炎症 (PE) 涉及免疫调节失调,在促炎性 (IL-6) 和抗炎性 (IL-10) 细胞因子之间存在失衡.
- 尼普里林素 (NEP) 是一种金属蛋白酶,对炎症敏感,并影响血管度.
研究的目的:
- 调查尼普利辛 (NEP) 水平 (mRNA和蛋白质) 与孕前炎症炎症标志物之间的相关性.
- 评估NEP在评估产前症严重程度方面的作用.
主要方法:
- 从52名PE患者和47名对照人群中采集了胎盘组织和血液样本.
- 测量了IL-6,TGF-β,IL-10和NEP mRNA的基因表达.
- 使用ELISA量化NEP蛋白水平.
主要成果:
- 在PE患者中,NEP mRNA和蛋白与促炎性标记物IL-6和TGF-β显著正相关.
- NEP水平与抗炎性细胞因子IL-10具有显著的反相关性.
- 在NEP水平和产前症严重程度之间观察到强烈的正相关性.
结论:
- 在患者中,NEP,炎症和孕前的严重程度之间存在实质性的关系.
- 尼普里利辛 (NEP) 显示出作为预孕前诊断和预后的生物标志物的潜力.
相关概念视频
01:33Hormonal Regulation
33.2K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.2K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
648
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
648
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
95
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
95
01:17Hormonal Regulation of Blood Pressure
2.6K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K