体重指数 (BMI) 较高对COVID-19后病情患者的快乐度的影响:二次分析
Gia Han Le1,2, Angela T H Kwan1,3, Sabrina Wong1,4
1Brain and Cognition Discovery Foundation, 77 Bloor Street West, Suite 617, Toronto, ON, M5S 1M2, Canada.
Advances in therapy
|December 20, 2023
概括
较高的身体质量指数 (BMI) 与COVID-19后病情 (PCC) 患者的快乐度降低有关. 这一发现表明,BMI可能会影响长期COVID患者的奖励系统功能.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 后COVID-19状态 (PCC) 涉及持续影响福祉的症状,包括快乐的基调.
- 肥胖是COVID-19和PCC的风险因素,与受损的快乐度有关.
- 了解PCC中肥胖和享乐基调之间的关系对于开发干预措施至关重要.
研究的目的:
- 调查PCC患者体质指数 (BMI) 升高与享乐性度之间的关联.
- 分析PCC中认知障碍的伏尔提奥塞丁临床试验的基线数据.
主要方法:
- 对一项随机,双盲,安慰剂对照试验进行了后期分析.
- 一般化的线性模型分析了基线数据,以评估BMI和快乐性语调 (通过SHAPS分数测量) 之间的关系.
- 统计模型根据包括年龄,性别,种族,COVID-19状态,酒精消费和收入在内的共同变量进行了调整.
主要成果:
- 分析包括了147名参与者的基线数据.
- 在BMI和SHAPS总得分之间发现了统计学上显著的积极关联 (p=0.045).
- 增加的BMI与自我报告的奖励系统功能缺陷相关.
结论:
- 在PCC患者中,更高的BMI与更大的享乐性音调缺陷有关.
- 这种关联可能会影响奖励预测和处理,强调神经生物学研究的必要性.
- 在PCC的治疗开发中考虑基线BMI可能是有益的.
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