双碳酸的溶液可以改善手术期间的酸平衡,并在已故捐赠者的肝脏移植后降低肝细胞酶水平:一项随机对照研究
Qingkai Li1, Ying Liu1, Yanan Wang1
1Department of Aesthesiology, The Third Hospital of Hebei Medical University, Shi Jiazhuang, 050051, China.
BMC anesthesiology
|December 20, 2023
概括
与乙烯酸 (AR) 溶液相比,双碳酸 (BR) 溶液改善了 орто型肝移植 (OLT) 患者的酸平衡和早期肝功能. 此外,BR还减少了晚期损伤,这表明它在OLT中的优势.
科学领域:
- 移植手术 移植手术
- 麻醉学 麻醉学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 双碳酸灵格 (BR) 溶液提供了独立于肝脏和脏代谢的直接缓冲.
- 乙酸的灵格 (AR) 溶液通常用于肝移植.
- 在OLT期间优化酸平衡和器官功能至关重要.
研究的目的:
- 为了比较BR溶液与AR溶液在OLT期间改善酸平衡的疗效.
- 评估BR和AR溶液对OLT后肝脏和功能的影响.
- 确定BR溶液是否能更好地保护肝移植功能和结局.
主要方法:
- 这项研究涉及69名接受正体肝移植 (OLT) 的成年患者.
- 患者接受BR溶液或AR溶液作为输注的晶体质和移植洗.
- 主要结局:对pH和基过量 (BE) 的影响;次要结局:使用二碳酸,肝脏和脏功能标志物.
主要成果:
- 与AR组相比,BR组在OLT的关键阶段显示了pH和基过剩 (BE) 的显著改善.
- 在BR组中,手术内注入二碳酸的发生率和量明显较低.
- 手术后肝酶 (AST) 和功能标志物 (肌素) 在BR组分别在7天和30天更好.
结论:
- 与AR溶液相比,BR溶液在OLT患者中显示出优异的手术内酸管理.
- BR溶液可能会保护早期的术后肝移植功能.
- BR溶液与晚期术后损伤的减少有关,这表明对功能有潜在的益处.
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