新辅助性皮洛替尼加特拉斯图祖马布和治疗HER2阳性乳腺癌的化疗:一项前性队列研究
Lu Liu1, Mingzhi Zhu1, Yanyan Wang1
1Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China.
World journal of surgical oncology
|December 20, 2023
概括
皮罗替尼与标准化疗相结合,在HER2阳性乳腺癌患者中显著改善了病理完整反应率. 这种pyrotinib加EC-TH疗法在新辅助乳腺癌治疗中表现出卓越的疗效和可控的安全性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- HER2阳性乳腺癌需要有效的新辅助疗法.
- 皮洛替尼 (P) 结合埃皮鲁比,环胺,塔克桑和特拉斯图祖马布 (EC-TH) 是一种潜在的新辅助疗法.
- 预测生物标志物如p53,p63和EGFR状态对于治疗选择至关重要.
研究的目的:
- 评估pyrotinib加EC-TH治疗方案的疗效和安全性.
- 评估p53,p63和EGFR状态对新辅助治疗结果的预测价值.
主要方法:
- 一项前性研究包括138名HER2阳性乳腺癌患者.
- 病例组 (n=55) 接受P+EC-TH;对照组 (n=83) 接受EC-TH.
- 统计分析包括千平方,费舍尔的精确测试和后勤回归.
主要成果:
- 与EC-TH组相比,P+EC-TH组的总病理完整响应 (tpCR) 和乳腺病理完整响应 (bpCR) 率 (63.64%和69.09%) 显着更高 (39.76%和44.58%).
- 总体应答率 (ORR) 在P+EC-TH组为100%,而EC-TH组为95.18%.
- p53阳性状态预测了更高的tpCR和bpCR;ER,PR和AR负面性也与更好的tpCR相关. 在P+EC-TH组中观察到高血和腹的增加,但可以控制.
结论:
- 皮洛替尼加EC-TH方案是有效和安全的新辅助疗法在HER2阳性乳腺癌.
- 将pyrotinib添加到EC-TH疗法中可以提高tpCR和bpCR的比率.
- ER,PR,AR和p53状态可以作为预测新辅助治疗反应的生物标志物.
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