与口腔白血病和口腔状细胞癌相关的唾液微生物群的组成和功能变化:一个病例对照研究
Qingying Lan1, Chang Zhang1, Hong Hua1
1Department of Oral Medicine, National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing, 100081, China.
BMC oral health
|December 20, 2023
概括
在口腔状细胞癌 (OSCC) 和口腔白血病 (OLK) 患者中,唾液细菌的组成和功能不同. 细菌的新陈代谢,特别是氨基酸如氨酸和氨酸的新陈代谢,可能会推动口腔癌的进展.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 转基因组学是指转基因组学.
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的恶性瘤,发病率正在上升.
- 口腔白血病 (OLK) 是一种癌前病变,具有高恶性转变潜力.
- 唾液微生物群在OSCC和OLK进展中的作用仍然不完全理解.
研究的目的:
- 将OSCC和OLK患者的唾液细菌组成和功能概况与健康对照 (HC) 进行比较.
- 调查唾液微生物群变化与口腔癌发展之间的潜在关联.
主要方法:
- 甲基因组测序用于分析18名OSCC患者,21名OLK患者和21名HC患者的唾液细菌.
- 斯皮尔曼相关性分析被用来识别细菌功能与特定类型之间的联系.
主要成果:
- 在OSCC,OLK和HC组中观察到唾液微生物群组成的显著差异.
- 吉梅拉是OSCC中最丰富的属. 在OLK和OSCC中,特定的Streptococcus和Gemella物种的增加.
- OSCC与代谢功能的改变有关,包括脂质,碳水化合物和糖代谢. 半氨酸和氨酸的代谢途径显著不同,在OSCC中最高,在HC中最低,G. haemolysans与这些途径相关.
结论:
- 在OSCC和OLK中,唾液微生物群的组成和功能发生了显著的变化,这表明在口腔癌的进展中发挥了作用.
- 细菌的新陈代谢,特别是非必需的氨基酸,如氨酸和氨酸,可能在口腔瘤发生过程中至关重要.
- 需要进一步的研究来阐明将细菌代谢与口腔癌发展联系在一起的机制.
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