糖尿病前期增加了主要四肢和心血管事件的风险
Jung-Chi Hsu1,2, Yen-Yun Yang3, Shu-Lin Chuang3
1Division of Cardiology, Department of Internal Medicine, National Taiwan University Jinshan Branch, New Taipei City, Taiwan.
糖尿病前期增加了主要不良肢体事件 (MALE) 和主要不良心血管事件 (MACE) 的风险,即使在较低的HbA1c水平. 这些并发症可以在糖尿病前期的早期开始,突出显示需要进行干预.
科学领域:
- 内分泌学和新陈代谢学
- 心血管研究研究心血管研究
- 血管医学 血管医学
背景情况:
- 在全球范围内,糖尿病前期的患病率正在上升.
- 严重的糖尿病前期存在类似于糖尿病的风险.
- 糖尿病前期和外周动脉疾病之间的联系还没有得到充分研究.
研究的目的:
- 调查糖尿病前期和肢体不良反应和心血管事件之间的关联.
- 为了确定在糖尿病诊断之前是否出现风险.
主要方法:
- 对36950名成年患者 (2014-2019) 的回顾性队列研究.
- 电子医疗记录的分析.
- 使用多变量Cox回归和Kaplan-Meier分析用于MALE和MACE.
主要成果:
- 糖尿病前期患者与正常葡萄糖调节 (NGR) 个体相比,MALE和MACE的发病率增加.
- 前糖尿病显著增加了MALE风险 (aHR 1.26) 和MACE风险 (aHR 1.46).
- 在HbA1c低至5.0-5.5%的情况下观察到MALE风险增加;在HbA1c>5.5%的情况下观察到MACE风险增加.
结论:
- 糖尿病前期增加了对MALE和MACE的敏感性,即使HbA1c水平较低.
- 副作用可能在糖尿病前期早期显现.
- 强化生活方式的修改可以改善严重糖尿病前期的结果.
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