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Updated: Jul 25, 2026

Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat
Published on: February 7, 2011
禁食肝胰岛素清除反映了食后肝胰岛素清除:简要报告
Tsuyoshi Okura1, Risa Nakamura2, Sonoko Kitao2
1Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan. ohkura@tottori-u.ac.jp.
禁食肝胰岛素清除率 (HIC) 与2型糖尿病 (T2DM) 和非糖尿病患者的食后肝胰岛素清除率有很强的相关性. 这表明禁食HIC是评估胰岛素清除的方便标记.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病研究 糖尿病研究
背景情况:
- 肝脏胰岛素清除率 (HIC) 是2型糖尿病 (T2DM) 病理生理学的关键因素.
- 在T2DM和代谢综合征中观察到降低HIC.
- 目前的HIC计算方法 (OGTT) 对于明显的糖尿病来说是繁重和危险的.
研究的目的:
- 调查禁食和食后HIC之间的相关性.
- 确定禁食HIC是否可以作为食后HIC的替代标记.
- 在T2DM和非糖尿病患者中评估这种相关性.
主要方法:
- 对70名受试者 (31名T2DM,39名非DM) 进行了食耐受性测试和高胰岛素-高血糖.
- 禁食HIC是使用禁食C-/胰岛素比率计算的.
- 饭后的HIC是使用饭后CAUC/胰岛素AUC比率计算的.
主要成果:
- 在T2DM (r=0.82) 和非DM (r=0.71) 受试者中发现禁食和食后HIC之间的显著相关性.
- 在T2DM中禁食HIC与BMI,HbA1c,GGT,HOMA-IR,HOMA-beta,M/I和全身胰岛素清除相关.
- 非DM患者的禁食HIC与HOMA-IR和HOMA-beta相关.
结论:
- 禁食HIC与T2DM和非糖尿病患者的食后HIC有很强的相关性.
- 禁食HIC显示出作为评估肝脏胰岛素清除的方便和可靠标记物的潜力.
- 这一发现简化了HIC评估,避免了繁的负载后测试.
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