相关实验视频

Updated: Jul 8, 2025

Zebrafish Model of Neuroblastoma Metastasis

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

DPY30通过上调ZEB1的转录表达来促进结直肠癌转移

Chun-Ying Luo^1,2, Wei-Chao Su³, Hai-Feng Jiang⁴

¹Medical College, Guangxi University, Nanning, 530004, Guangxi Province, People's Republic of China.

Cancer cell international

|December 20, 2023

概括

DPY30蛋白通过增强表皮-介质细胞转变 (EMT) 来促进结直肠癌 (CRC) 转移. 针对DPY30可能为CRC患者提供新的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

DPY30是基因组 lysine 甲基转移酶复合物的核心组成部分,参与瘤发生和细胞衰老.
DPY30在结直肠癌 (CRC) 进展和转移中的作用仍然在很大程度上是未知的.

研究的目的:

为了研究DPY30在CRC转移中的生物功能.
阐明DPY30在CRC中的作用的基础分子机制.

主要方法:

使用CRC细胞系 (HT29,SW480) 的体外和体内实验.
分析DPY30表达与临床病理特征的相关性.
细胞迁移,入侵和肺转移的评估.
研究DPY30对基因素H3K4三甲基化 (H3K4me3) 和ZEB1表达的作用.

主要成果:

在CRC中,DPY30过度表达与淋巴结转移和上皮-介质细胞过渡 (EMT) 有积极的相关性.
在体外,DPY30 Knockdown显著抑制了EMT,细胞迁移和入侵.
在体内,DPY30降低了肺瘤转移.
通过增加ZEB1转录,DPY30上调H3K4me3水平,并促进EMT和CRC转移.

结论:

DPY30在通过ZEB1-介导的EMT途径促进CRC转移方面发挥着关键作用.
DPY30代表了结直肠癌的潜在治疗标和预后生物标志物.

关键词:

结肠直肠癌是什么意思 DPY3030 是一个很好的项目.在EMT中,EMT是EMT.H3K4me3是什么意思 H3K4me3是什么意思转移转移转移转移在ZEB1中,ZEB1是指ZEB1.

更多相关视频

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...