静态负荷与乳腺癌风险之间的关联:一项队列研究
Yufan Guan1, Jie Shen2, Juan Lu1
1Departments of Family Medicine and Population Health, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Breast cancer research : BCR
|December 20, 2023
概括
较高的全静电负荷 (AL),衡量慢性压力,与女性乳腺癌风险增加有关. 这一发现表明,AL可能有助于预测和分层乳腺癌风险.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 压力生理学 压力生理学
背景情况:
- 静态负荷 (AL) 量化了累积的终身压力.
- 之前的研究将更高的AL与乳腺癌患者的不良结果联系在一起.
- 艾滋病与乳腺癌发病率之间的关联仍在调查中.
研究的目的:
- 研究全静电负荷与患乳腺癌的风险之间的关系.
- 确定AL是否是乳腺癌风险的独立预测因素.
主要方法:
- 来自英国生物银行的181,455名女性的分析.
- 从2006年到2020年进行纵向跟进.
- 考克斯回归和分类分析,调整多个风险因素和多基因风险评分 (PRS).
主要成果:
- 较高的AL与乳腺癌发病率的增加显著相关 (HR=1.05每单位增加).
- 与最低的AL组相比,最高AL组的女性的风险增加了1.17倍.
- 在AL和已知的风险因素 (如年龄,家族史和生活方式) 之间观察到的联合效应.
结论:
- 增加的全静电负荷是女性乳腺癌的重要危险因素.
- 艾滋病和乳腺癌风险之间的关联是独立于已确定的风险因素.
- 静态负荷显示了作为乳腺癌风险预测和分层的生物标志物的潜力.
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