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在HBV复发后,HBcrAg水平对HBsAg血清转化的影响:一个病例报告

Maki Ohkubo^1,2, Kuniaki Fukuda³, Shigeru Chiba⁴

¹Department of Pharmacy, University of Tsukuba Hospital, Ibaraki, Japan.

Journal of pharmaceutical health care and sciences

|December 20, 2023

概括

在核糖类相似物停止后,B型肝炎病毒 (HBV) 的反弹可能导致B型肝炎表面抗原 (HBsAg) 血清转化. 乙肝核心相关抗原 (HBcrAg) 可能预测这种反弹和随后的血清转化.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

核酸相似物 (NA) 用于B型肝炎病毒 (HBV) 的重新激活,但并不总是实现HBsAg血清转化.
停止NAs可以导致HBV反弹,而HBcrAg的预测价值仍在争论中.

研究的目的:

在NA停止后报告HBV反弹的病例,导致HBsAg血清转化.
研究HBcrAg在预测HBV反弹和HBsAg血清转化中的作用.

主要方法:

一名 HBV 感染已消失的患者接受了利图西玛布,导致 HBV 活性化和恩特卡维尔治疗.
当HBV-DNA变得无法检测时,安特卡维尔被停止使用,但HBcrAg仍然为阳性,在病毒反弹之前.
控制了HBV的重新激活,尽管最初的反弹,但仍观察到HBsAg血清转化.

主要成果:

在停用恩特卡维尔141天后,HBV复发发生,HBcrAg可检测,HBV-DNA无法检测.
尽管最初情况恶化,但该患者实现了HBsAg血清转化,HBcrAg和HBV-DNA无法检测.
在第二次停用恩特卡维尔后,没有检测到进一步的HBV活性.

结论:

停止NA可以诱导HBV反弹,导致HBsAg血清转化.
在无法检测的HBV-DNA中检测到的HBcrAg可以预测HBV反弹和随后的HBsAg血清转化.
需要进一步的前性研究来证实HBcr.Ag的预测价值.

关键词:

乙型肝炎病毒重新激活在HBV的反弹中,HBV的反弹.在HBcrAg水平上.在HBsAg血清转化过程中.

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