在parosmia中的功能连接模式
Divesh Thaploo1, Akshita Joshi2, Eren Yilmaz3
1Smell & Taste Clinic, Department of Otorhinolaryngology, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Taploodivesh4@gmail.com.
Behavioral and brain functions : BBF
|December 20, 2023
概括
嗅觉障碍帕洛斯米亚 (parosmia) 与嗅觉区域的大脑连接性降低有关. 这项研究使用功能性MRI显示记忆,决策和嗅觉处理中心之间的信息流动受损在患有parosmia的患者.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉研究 嗅觉研究
- 医疗成像医学成像
背景情况:
- 帕洛斯米亚是一种质的嗅觉功能障碍,其特点是对气味的感知有所扭曲.
- 了解帕洛斯米亚中中枢神经系统的变化对于诊断和治疗至关重要.
研究的目的:
- 通过静止状态的功能连接来研究中枢神经系统内嗅觉处理的变化.
- 为了确定受帕洛斯米亚影响的特定大脑网络和区域.
主要方法:
- 一项涉及145名被诊断患有帕洛斯米亚的患者的横截面研究.
- 标准化问卷和嗅觉测试 (嗅探棒) 用于诊断.
- 休息状态功能磁共振成像 (fMRI) 扫描使用3T扫描仪获得.
主要成果:
- 全脑分析显示,突出和执行控制网络的功能连接性减少.
- 对感兴趣区域的分析显示,初级/二级嗅觉区域 (极,上边环,轨道前皮层) 和嗅觉皮层 (皮层) 之间的连接性下降.
结论:
- 患有帕洛斯米亚的患者表现出记忆,决策中心和初级/二级嗅觉区域之间的功能连接性降低.
- 这些发现表明,在parosmia中,嗅觉感知和整合的基础是神经通路的破坏.
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