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A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
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照射和骨质放射性骨中的微观结构变化:一项SEM研究

P Sridhar Reddy1, Kaapo Villikka1, Bina Kashyap1

  • 1Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.

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概括

放射治疗显著改变人类下的微观结构,减少骨,骨细胞和血管. 这些通过扫描电子显微镜 (SEM) 观察到的变化增加了长期患骨质放射缩 (ORN) 的风险.

关键词:
辐射辐射是一种辐射.下巴 下巴 是一个很大的问题.这些骨质细胞是骨质细胞.骨质放射性衰老 (osteoradionecrosis) 是一种严重的疾病.扫描电子显微镜扫描电子显微镜

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科学领域:

  • 口腔和牙面部外科手术
  • 生物材料科学 生物材料科学
  • 放射学 放射学是一门学科.

背景情况:

  • 对头癌的放射治疗可能会对下骨代谢和愈合产生负面影响.
  • 骨放射性死 (ORN) 是放射治疗的严重并发症,其特征是骨死亡和受损愈合.
  • 了解放射治疗引起的微观结构变化对于管理ORN风险至关重要.

研究的目的:

  • 通过扫描电子显微镜 (SEM) 来研究放射治疗后人类下骨中的微结构变化.
  • 为了比较对照组,照射组和骨质放射性死 (ORN) 患者组之间的骨微结构参数.

主要方法:

  • 皮皮质骨活检从三个组中收集:对照组,照射组和ORN患者.
  • 骨样本经过了光显微镜和扫描电子显微镜 (SEM) 的准备.
  • SEM分析量化了骨,哈弗斯通道 (HC),骨直径 (D.O),HC直径 (D.HC),骨壁厚度 (O.W.Th),骨细胞和骨细胞树突.

主要成果:

  • 与对照组相比,照射和ORN骨样本显示骨,DO,DHC,OWTh,骨细胞和骨细胞树突的显著减少 (p < .05).
  • 在照射和ORN骨中观察到哈弗斯通道 (HC) 的非显著减少.
  • 长期的辐射效应 (>5年) 表明骨质,结构,细胞性和血管性逐渐恶化.

结论:

  • 放射治疗导致人类下的显著长期微观结构损伤.
  • 这些微观的变化会损害骨质量,细胞性和血管性,增加对ORN的易感性.
  • SEM为辐射诱导的骨损伤和ORN的病变产生提供了宝贵的见解.