通过diosgenin改变肠道微生物群,在的小鼠模型中调解了抗作用
Xinyu Li1,2, Jing Li1, Jia Ji1
1Department of Cell Biology and Neurobiology, Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Journal of neurochemistry
|December 20, 2023
概括
天然化合物迪奥斯基宁通过积极影响肠道细菌和减少神经炎症,在治疗方面表现有前途. 这项研究表明,在小鼠模型中,它有潜力缓解发作和改善认知功能.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 迪奥斯基宁是一种天然的类固醇沙宁,因其在神经退行性疾病中的治疗潜力而得到认可.
- 迪奥斯基宁在中的作用及其与肠道微生物群的相互作用尚未得到充分了解.
- 现有的研究强调了迪奥斯基宁对阿尔茨海默病,帕金森病,多发性硬化症和中风的影响.
研究的目的:
- 为了研究迪奥斯基宁的抗作用.
- 探索迪奥斯基宁,肠道微生物群调节和之间的联系.
- 阐明迪奥斯基宁在中神经保护作用的潜在机制.
主要方法:
- 在小鼠模型中使用乙 (PTZ) 诱导.
- 外源性迪奥斯基宁的使用和活动,认知功能和神经元损伤的评估.
- 16S核糖体RNA (16SrRNA) 测序以分析肠道微生物群的组成.
- 便微生物群移植 (FMT) 实验,以确认肠道微生物群的作用.
- 对肠道质细胞 (EGC) 激活,TLR4-MyD88通路,炎症性细胞因子和肠道屏障功能的分析.
主要成果:
- 迪奥斯基宁治疗显著减少了PTZ诱导的发作,学习缺陷和海马神经元损伤.
- 在性小鼠模型中,迪奥斯基宁的使用逆转了Bacteroides和Parabacteroides属的减少.
- FMT实验证实,迪奥斯基宁对的神经保护是由肠道微生物群调节的介导.
- 迪奥斯基宁和FMT抑制了EGC激活和TLR4-MyD88通路,减少了结肠炎症并改善了肠道屏障功能.
结论:
- 迪奥斯基宁调节肠道微生物群,缓解肠道炎症和神经炎症,从而抑制的进展.
- 这项研究确定了迪奥斯基宁作为和相关疾病的潜在治疗剂.
- 迪奥斯基宁的机制涉及肠道微生物群的调节和抑制炎症途径.
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