多发性硬化症前症候群中的胃肠道疾病
Fardowsa L A Yusuf1,2, Feng Zhu1, Charity Evans3
1Medicine (Neurology), the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia, V6T 2B5, Canada.
Annals of clinical and translational neurology
|December 20, 2023
概括
在多发性硬化症 (MS) 诊断前五年,胃肠道问题更为频繁. 这些发现表明胃肠道症状可能表明早期的MS,观察到显著的性别差异.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种具有复杂病因的慢性神经系统疾病.
- 胃肠道 (GI) 功能障碍在MS患者中经常被报告,但其在疾病早期的作用不太清楚.
研究的目的:
- 检查GI相关的医生访问和药物处置在第一个脱髓化事件或MS发病前五年之间的关联.
- 在MS诊断之前调查GI症状呈现的潜在性别差异.
主要方法:
- 利用了来自不列颠哥伦比亚省 (1996-2013) 的相关行政和临床数据.
- 确定了MS病例的行政队列 (n=6863) 和临床队列 (n=966),与匹配的对照.
- 在指数日期前的五年中,使用负二项式和强大的Poisson模型比较了GI相关的医生访问和药物处方.
主要成果:
- 多发性硬化症病例显示,胃炎,十二指肠炎和食道疾病的医生访问率显着更高.
- 多发性硬化病例有更大的风险处方与便秘相关的药物,抗药和推进剂.
- 与女性相比,男性对推进性药物处方的相对风险不成比例地高.
结论:
- 与胃肠道相关的医生访问和药物处方在第一个脱髓化事件或MS发病前的五年中更为常见.
- 胃肠道症状代表了MS的前期或早期阶段的可测量特征.
- 在MS的早期阶段,消化道症状呈现的性别差异很明显.
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