输液成像的ISMRM开放科学倡议 (OSIPI):来自OSIPI-动态对比增强挑战的结果
Eve S Shalom1,2, Harrison Kim3, Rianne A van der Heijden4,5
1School of Physics and Astronomy, University of Leeds, Leeds, UK.
Magnetic resonance in medicine
|December 20, 2023
概括
像Ktrans这样的定量成像生物标志物对于癌症评估至关重要,但缺乏标准化. OSIPI-DCE挑战揭示了不同软件的Ktrans测量的显著变化,突出了对标准化方法的需求.
科学领域:
- 医疗成像医学成像
- 量化MRI是指数量化的MRI.
- 无线电学 (Radiomics) 是一种辐射学.
背景情况:
- 定量成像生物标志物,如Ktrans,对于瘤诊断,预后和治疗反应评估至关重要.
- 目前用于Ktrans量化的软件工具缺乏标准化,导致结果不一致.
- 国际医学磁共振学会 (ISMRM) 针对输液成像-动态对比增强 (OSIPI-DCE) 挑战的开放科学倡议成立,以解决这一标准化缺口.
研究的目的:
- 通过使用动态对比增强MRI (DCE-MRI) 对Ktrans量化进行不同软件管道的比较.
- 在各种分析方法中评估Ktrans测量的准确性,可重复性和可重复性.
- 确定影响Ktrans估计变量的因素,并促进标准化工作.
主要方法:
- 开发了一个标准化的框架来评估DCE-MRI分析管道产生的Ktrans值.
- perfusion MRI 专家使用临床和合成数据提交了他们对质母细胞瘤的 Ktrans 量化管道.
- 提交的内容包括Ktrans值,使用的软件和标准操作程序,这些都是使用Ktrans评分 (准确性,可重复性,可重复性) 来评估的.
主要成果:
- 在10个提交的项目中,Ktrans的得分差异很大 (28%78%,中位数为59%).
- 精度,可重复性和可重复性分数分别在0.540.92,0.640.86和0.651.00之间.
- 手动动脉输入功能的选择显著影响了可重复性,显示出比自动化方法更大的可变性;详细的标准操作程序改善了可重复性.
结论:
- 在OSIPI-DCE挑战中,Ktrans估计的软件间差异显著.
- 该研究提供了一个基准测试框架,并为Ktrans量化方法的持续评估提供了分数.
- 在临床实践中,标准化协议和自动化方法对于可靠和可重复的Ktrans测量至关重要.
关键词:
在DCE-MRI中,使用的是DCE-MRI.挑战 挑战 挑战 挑战数据分析数据分析数据分析质母细胞瘤是一种质母细胞瘤.开放科学是一个开放的科学.perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion 这是一个非常重要的方法,它可以让一个人成为一个非常重要的角色,一个非常重要的角色,一个非常重要的角色,一个非常重要的角色,一个非常重要的角色,一个非常重要的角色,一个非常重要的角色,一个非常重要的角色.
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