随着时间的推移,抗生素混合的腹透析溶液的无菌性
Ken-Soon Tan1,2,3, Robyn Rogers1, Deanna Shephard1
1Department of Kidney services, Logan hospital, Meadowbrook, QLD, Australia.
概括
抗生素混合腹膜透析 (PD) 溶液在使用无菌技术制备和室温储存时保持无菌性长达72小时. 这一发现支持延长存储时间,可能减少PD治疗患者每日去诊所的次数.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 腹膜透析 (PD) 相关的腹膜炎通常需要每天服用腹膜内抗生素,长达三周.
- 由于污染问题,一些地区的现行法规要求在24小时内使用抗生素混合的PD溶液.
- 这种24小时的限制需要频繁的患者诊所访问或昂贵的家庭分娩服务.
研究的目的:
- 为了研究抗生素或无菌水混合后在PD溶液中微生物生长的潜力.
- 评估抗生素混合PD溶液的稳定性和无菌性.
主要方法:
- 12个PD溶液袋被混合在塞法佐林中,12个被混合在无菌水中,使用无菌技术.
- 所有混合的袋子都储存在室温下.
- 微生物学培养是在0,24,48,72小时采集的样本上进行的.
主要成果:
- 一个无菌的混合水袋显示了Corynebacterium spp. 在24小时内,但在第九天是负面的.
- 所有其他的无菌水和Cefazolin混合的PD溶液在所有测试时间点 (0-72小时) 都保持无菌.
结论:
- 无菌地准备的与抗生素混合的PD溶液在室温下存储,可在72小时内无菌.
- 这种稳定性使得可以安全地向患者发放多达三天的抗生素混合PD袋.
- 延长存储时间可以提高患者的便利性,减少医疗保健系统的负担.
相关概念视频
01:15Dialysis
693
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
693
01:15Drug Elimination by Renal Route: Tubular Secretion
2.4K
Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
2.4K