肺非典型癌的预后诺莫和流行病学分析:一个SEER数据库和外部验证研究
Xinglin Yi1, Yi He2, Gangzhen Qian2
1Department of Respiratory Medicine, Third Military Medical University Southwest Hospital, Chongqing, China.
Cancer medicine
|December 20, 2023
概括
这项研究揭示了肺癌 (肺癌) 率的上升,并确定了亚叶切除作为早期非典型癌症 (AC) 肺癌的可行选择. 一种新型的诺摩图谱有助于预测AC预后.
科学领域:
- 肺部瘤学 肺部瘤学
- 流行病学 流行病学
- 手术瘤学手术瘤学
背景情况:
- 肺癌,包括非典型癌 (AC) 和典型癌 (TC),代表了肺神经内分泌瘤的重要群体.
- 了解它们的流行病学分布和预后因素对于有效的患者管理至关重要.
研究的目的:
- 描述肺癌 (AC和TC) 的流行病学.
- 为了确定非典型的癌 (AC) 的独立预后因素.
- 开发一个AC预后的诺米图,并评估外科手术对AC特定存活率 (ACSS) 的影响.
主要方法:
- 结合点回归和流行病学趋势的年龄组分布.
- 预后因子识别的单变量和LASSO-Cox回归.
- 诺摩图和基于网络的预测器开发用于AC预后.
- 卡普兰-梅尔分析和手术结果的G计算.
主要成果:
- 分析了1132名患者;AC患者的平均寿命为63.4年,其中79.8%的人有吸烟史.
- 观察到AC和癌类瘤的年均发病率上升.
- 诺莫格拉姆在预测1年,3年和5年的AC存活率方面表现出色的准确性.
- 在早期到晚期的疾病中,亚叶切除显示了与带切除相比的非劣势生存结果.
结论:
- 首次详细研究了十年来和各个年龄组的肺癌类流行病学趋势.
- 亚叶切除可能是早期AC的合适的外科选择.
- 开发出来的名图和计算器提供了实际的预测工具.
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