果消费对血管健康和免疫功能的影响
Robert J Castro1, Kazandra Pedroza1, Mee Young Hong1
1School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, 92182, USA.
Metabolism open
|December 20, 2023
概括
每天的果消费通过减少VCAM-1和增加SOD,CAT和GPx等抗氧化剂,改善了超重成年人的血管健康. 这表明果可能有助于减轻动脉样硬化和氧化应激风险.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 免疫学 免疫学 免疫学
背景情况:
- 由动脉样硬化引起的心脏病是导致死亡的主要原因.
- 血管完整性是减轻动脉样硬化风险的关键.
- 果含有有益的化合物,但它们对超重/肥胖成年人的血管和免疫效应尚未得到充分研究.
研究的目的:
- 为了检查果消费对血管健康标志物的影响.
- 评估果摄入量对免疫功能指标的影响.
- 专门研究超重和肥胖成年人的这些影响.
主要方法:
- 一项为期12周的交叉研究,涉及27名超重/肥胖参与者.
- 每天摄入100千卡的果或同热量低脂肪饼干.
- 血液标记物的分析包括VCAM-1,ICAM-1,P-选择素,E-选择素,sCD4,sCD8,sCD3E,sCD45,TNF-α,CAT,GPx和SOD.
主要成果:
- 在4周和12周,果消费显著降低了VCAM-1水平 (P≤0.046).
- 抗氧化酶活性增加:CAT (P=0.035) 和GPx (P<0.05) 在12周.
- 在12周,果摄入量与饼干摄入量 (P=0.046) 相比,超氧化物脱酶 (SOD) 显著更高 (P=0.046).
结论:
- 果的消费可以通过降低VCAM-1来增强血管完整性.
- 增加的SOD,CAT和GPx表明氧化应激减少.
- 果代表了一种潜在的饮食策略,用于控制动脉样硬化和氧化应激风险因素.
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