患有乙性食道炎的女性的怀孕结果:全国性基于人口的研究
Lovisa Röjler1, Amiko M Uchida2,3, John J Garber3
1Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.
Inflammatory intestinal diseases
|December 20, 2023
概括
研究人员检查了患有异性食道炎 (EoE) 的人的怀孕结果. 这项研究没有发现EoE患者早产风险增加,尽管低出生体重需要进一步调查.
科学领域:
- 胃肠病学 胃肠病学
- 过敏 免疫学 免疫学
- 生殖医学 生殖医学
背景情况:
- 性食道炎 (EoE) 是一种慢性过敏炎症,影响食道的疾病.
- EoE主要影响生活的第二和第三十年的人.
- 关于被诊断患有EoE的妇女怀孕后果的数据有限.
研究的目的:
- 在全国范围内的一组患有EoE的女性中调查母亲和胎儿的结果.
- 为了确定EoE是否与早产风险增加有关.
- 评估其他二次胎儿和母体妊娠并发症.
主要方法:
- 在全国基于人口的队列中使用了经过验证的EoE组织病理学诊断.
- 对EoE的女性和匹配的对照群之间的母亲和胎儿结局进行比较.
- 运用后勤回归来计算主要和次要结果的几率比率 (ORs).
主要成果:
- 这项研究确定了19名患有EoE的女性,她们在1992年至2016年间分娩.
- 在EoE队列 (4.3%) 和参考队列 (7.0%) 之间没有观察到早产率的显著差异.
- 在EoE组 (OR = 12.42) 中,低出生体重 (LBW) 的统计显著增加,尽管基于非常小的数字;其他胎儿和母亲的结局没有显著差异.
结论:
- 这项全国范围的队列研究没有发现异氨酸性食道炎与早产之间存在增加的关联.
- 虽然低出生体重显示出潜在的关联,但它是基于有限的数据,需要进一步研究.
- 与一般人群相比,EoE妇女的怀孕似乎具有与大多数常见不良结果相似的风险.
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