在DRE患者中,大脑网络功能连接和拓性质的变化
Yongqiang Ding1, Kunlin Guo2, Jialiang Li3
1Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in neurology
|December 20, 2023
概括
与健康个体相比,耐药性 (DRE) 患者表现出大脑网络拓的改变. 功能连接和网络属性的这些变化在不同的脑波频率上有所不同,为DRE病理生理学提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 的研究研究.
- 大脑网络分析 脑网络分析
背景情况:
- 是一种神经系统疾病,其特点是经常性发作.
- 耐药性 (DRE) 影响了大量患者,需要使用替代治疗策略.
- 了解DRE中潜在的大脑网络的改变对于开发向疗法至关重要.
研究的目的:
- 调查DRE患者和健康对照者 (HC) 之间的间歇期功能网络拓学的差异.
- 通过使用脑电图 (EEG) 来分析各种频段的网络特性变化.
- 为了解DRE病理网络变化提供理论基础.
主要方法:
- 对十名DRE患者和五名性别年龄匹配的HC患者的EEG数据的回顾性分析.
- 计算加权阶段滞后指数 (wPLI) 和网络属性 (集群系数,节点程度,总效率,特征路径长度).
- 对EEG数据进行带宽过,将其分为三角波,三角波,α,β和波频段,并进行统计分析和FDR校正.
主要成果:
- 与HC相比,DRE患者的整体功能连接性明显较低.
- 在全频带中,DRE显示集群系数,节点度和总效率下降,特征路径长度增加.
- 观察到特定频率的变化:在三角波段的连接性较低,在α,β和gamma波段的连接性更高;改变了网络属性和跨波段的特性路径长度.
结论:
- 与健康个体相比,DRE患者的功能网络拓显著改变.
- 这些拓变化在各种频段中表现得不同.
- 这些发现提供了对DRE特征的病理网络变化的基本理解.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.1K
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
11.2K
相关概念视频
01:37Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
01:01Neuroplasticity
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...