腎 sinus 脂肪與心臟代謝和腎素 - 血管新生素系統參數在初級 aldosteronism 之間的聯繫
Ryunosuke Mitsuno1, Kenji Kaneko1, Toshifumi Nakamura1
1Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Journal of the Endocrine Society
|December 20, 2023
概括
腎 sinus 脂肪累積與原發性 aldosteronism (PA) 的心臟代謝問題有關. 它与氨酸- ангиотензин系统参数的关联在PA亚型和性别之间存在差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 脏鼻脂肪 (RSF) 积累与心脏代谢疾病 (如肥胖,糖尿病,高血压和慢性病) 有关.
- 对于RSF在原发性阿尔多斯铁症 (PA) 中的临床意义尚不清楚.
研究的目的:
- 在PA患者中研究RSF体积和心脏代谢/血管系统 (RAS) 参数之间的关系.
- 为了区分单边和双边PA亚型之间的这些关系.
主要方法:
- 分析了45名单边和92名双边PA患者的数据.
- 测量RSF体积 (通过体积正常化,RSF%) 和与心脏代谢风险因素,RAS参数和完整的副甲状腺激素 (iPTH) 的相关性.
主要成果:
- 在单边PA和男性中,RSF%更高.
- 在所有PA患者中,RSF%与心脏代谢风险标志物 (年龄,BMI,内脏脂肪,肌素,脂质比率,尿酸,葡萄糖,CRP) 有正相关.
- 在双边PA中,RSF%与血中阿尔多素度 (PAC),阿尔多素与素的比率和iPTH正相关,但在单边PA中,尤其是女性中,并非如此.
- 在经过调整后,这些相关性在双边PA中的PAC和iPTH中持续存在.
结论:
- RSF积累有助于PA中的心脏代谢功能障碍.
- RSF体积和RAS参数之间的相关性根据PA亚型和性别有很大的差异.
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