肠道沙门菌和外膜囊泡是目前和未来的癌症治疗选择
Genesy Pérez Jorge1, Marco Túlio Pardini Gontijo2, Marcelo Brocchi1
1Universidade Estadual de Campinas (UNICAMP), Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Doenças Tropicais, Instituto de Biologia, Campinas, Brazil.
Frontiers in cellular and infection microbiology
|December 20, 2023
概括
沙门氏菌 (Salmonella enterica) 细菌及其外膜囊泡 (OMVs) 显示出作为癌症免疫疗法的前景. 这些细菌和OMV可以向瘤,刺激免疫反应,并提供抗癌剂,提供新的治疗途径.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 微生物学 微生物学
背景情况:
- 传统的癌症疗法面临着局限性.
- 细菌介导免疫疗法,特别是使用*Salmonella enterica*,正在成为一个有前途的替代方案.
- 对*S. enterica*的基因改造提高了它的安全性和抗瘤能力.
研究的目的:
- 审查基于*Salmonella enterica*的癌症免疫疗法的进展.
- 为了阐明Salmonella与癌症作斗争的机制.
- 突出S. enterica*衍生的外膜囊泡 (OMV) 作为免疫治疗剂和药物输送系统的潜力.
主要方法:
- 关于*Salmonella enterica*及其在癌症治疗中的应用的最新科学文献的综述.
- 对S. enterica*的内在抗瘤特性进行分析.
- 评估来自S. enterica的外膜囊泡 (OMV) 的治疗潜力.
主要成果:
- *Salmonella enterica*具有内在的瘤向,细胞杀伤和增殖能力.
- 转基因*S. enterica*作为药物输送和组合疗法的载体.
- 来自*S. enterica*的外膜囊泡 (OMVs) 显示出抗瘤功效,比活细菌更安全,并且可以作为纳米载体发挥作用.
结论:
- *Salmonella enterica*及其OMV代表了癌症免疫治疗的创新和有效策略.
- OMV是一种比活细菌更安全的替代品,能够刺激免疫反应并提供治疗剂.
- 对基于S. enterica的免疫疗法和OMV进行进一步的研究是有必要的,以充分实现它们的临床潜力.
相关概念视频
01:30Cancer Vaccines
370
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
370
01:27Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K