患有抗Jo1抗合成酶综合征和间歇性肺病的患者的肺微生物组变化
Teresa Quintero-Puerta1, Juan Alberto Lira-Lucio1, Ramcés Falfán-Valencia1
1HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Frontiers in cellular and infection microbiology
|December 20, 2023
概括
抗合成酶综合征 (ASSD) 患者的肺微生物组根据抗Jo1抗体不同,较低的Veillonella丰度与特定的免疫细胞变化有关. 这一发现可能会影响对ASSD肺损伤机制的理解.
科学领域:
- 肺部医学 肺部医学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 抗合成酶综合征 (ASSD) 是一种影响肺部的自身免疫性疾病.
- 肺微生物组在ASSD病原体中的作用尚未完全理解.
- 反Jo1自身抗体是一些ASSD患者的关键标记物.
研究的目的:
- 在ASSD患者的支气管洗液 (BALF) 中描述肺微生物组.
- 基于抗Jo1自身抗体阳性的肺微生物组进行比较.
- 为了评估肺部细菌,差异细胞数量和抗Jo1状态之间的相关性.
主要方法:
- 来自抗Jo1-阳性 (JoP,n=6) 和非Jo1-阳性 (NJo,n=17) ASSD患者的BALF的16S核糖体RNA基因测序.
- 对BALF的微分细胞计数分析.
- 斯皮尔曼对量化变量和细菌物种丰度的相关性分析.
主要成果:
- 与NJo患者 (4.1%) 相比,JoP患者 (2.2%) 的Veillonella基因显著减少.
- 在Veillonella丰富度和BALF细胞组成之间观察到高相关性 (rho ≥ ± 0.7,p < 0.05).
- 在JoP患者中,Veillonella的丰度与巨细胞 (rho = -0.77) 有负相关性,与乙素 (rho = 0.77),淋巴细胞 (rho = 0.77) 和Prevotella (rho = 1) 有正相关性.
结论:
- 肺微生物组的组成在ASSD患者中不同,可能会影响细胞反应,导致肺损伤.
- 反Jo1自身抗体的阳性与肺部Veillonella的丰度较低有关.
- 维龙氏菌的丰富性与肺中的特定免疫细胞 (巨细胞,乙酸细胞,淋巴细胞) 和其他细菌属 (Prevotella) 有着强烈的相关性.
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