没有任何伟大的东西都没有风险:罕见的庞布利祖马布诱导的下炎病例
Ashen Fernando1, Aastha Mittal1, Rashid Cheema2
1Department of Internal Medicine, Geisinger Medical Center, Danville, PA, USA 17822.
JCEM case reports
|December 20, 2023
概括
作为免疫检查点抑制剂的 pembrolizumab 可以引起低血压炎,这是一个罕见但严重的副作用. 早期诊断和治疗对于接受这种治疗的转移性癌症患者至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 布罗利祖马布是一种免疫检查点抑制剂,向编程细胞死亡蛋白1 (PD-1).
- 它有效治疗严重转移性癌症.
- 免疫检查点抑制剂可能会导致免疫相关的不良影响,包括内分泌病变.
研究的目的:
- 为了突出一例罕见的,由 pembrolizumab 诱导的低性炎.
- 强调高临床怀疑对于诊断ICI诱导的低体质炎的重要性.
- 强调迅速诊断和管理这种可能危及生命的内分泌异常的必要性.
主要方法:
- 案例报告的呈现方式.
- 对临床表现和治疗过程的审查.
- 讨论 pembrolizumab 和低体质炎之间的关联.
主要成果:
- 一名64岁的男性因肺癌而接受 pembrolizumab 治疗,患有低体质炎.
- 这一案例说明了pembrolizumab的一个罕见的不良反应.
- 这一案例强调了对内分泌并发症的警的必要性.
结论:
- 免疫检查点抑制剂诱导的低血炎是一种罕见但严重的担忧.
- 及时诊断和管理对于患者的安全至关重要.
- 瘤学家和内分泌学家必须意识到这种潜在的不良事件.
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