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与野火相关的烟雾吸入会使睡眠中断的老鼠心血管风险恶化

W Kyle Martin¹, M C Schladweiler², W Oshiro²

¹Curriculum in Toxicology and Environmental Medicine, UNC, Chapel Hill, NC, United States.

Frontiers in environmental health

|December 20, 2023

概括

暴露于树木烟雾 (EWS) 会加剧与老鼠睡眠障碍相关的心血管风险. 暴露于空气污染会放大睡眠不足引起的血压和心率的增加,可能是通过增加同情活动.

科学领域:

环境健康环境健康
心血管生理学心血管生理学
睡眠科学睡眠科学

背景情况:

睡眠不足与心血管疾病有关.
像空气污染这样的环境压力因素可能会加剧睡眠对心血管的影响.

研究的目的:

调查空气污染暴露是否会改变睡眠障碍对心血管的影响.
为了评估树木烟 (EWS) 对睡眠不足的老鼠的影响.

主要方法:

老鼠经历了轻微的睡眠丧失 (温柔的处理) 和ESW暴露.
评估血压,心率,心脏功能,炎症,基因表达和心率变化 (HRV).

主要成果:

睡眠障碍本身就增加了血压,心率,并改变了昼夜基因表达.
结合睡眠障碍和EWS暴露,在活跃期间心率和血压升高,先后是HRV降低.
暴露于EWS,睡眠受损的老鼠在暴露后表现出心脏输出和上腺激素基因表达的增加.

结论:

吸入的空气污染,像EWS一样,可能会增加与睡眠障碍相关的心血管风险.
增加的同情活动似乎是连接空气污染,睡眠障碍和心血管影响的关键机制.

关键词:

空气污染空气污染心血管疾病的风险.树的烟雾是的烟雾睡眠睡眠睡眠睡眠睡眠森林大火野火森林大火

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