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开发符合规格限制的尼加氨酸衍生物,用于强烈的读透活性

Noriko Omura1, Akihiro Taguchi1, Tomoki Kuwahara2

  • 1Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

ACS medicinal chemistry letters
|December 20, 2023
PubMed
概括

新的negamycin衍生物TCP-304和TCP-306对杜氏肌肉发育不良 (DMD) 突变表现出强大的读透活性. 这些形状受限的化合物恢复了dystrophin,为DMD提供了一个有前途的治疗途径.

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