在麻醉引起的意识丧失期间改变了动态整合/分离平衡
Louis-David Lord1,2, Timoteo Carletti2,3, Henrique Fernandes1,2,4
1Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Frontiers in network physiology
|December 20, 2023
概括
麻醉通过减少远程通信 (整合),同时保持局部处理 (分离) 来破坏正常的大脑功能. 这项研究使用电皮质谱 (ECoG) 来观察胺和醇下大脑动态的这些变化.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 正常的意识依赖于全球大脑整合和局部隔离之间的平衡.
- 包括麻醉在内的改变意识状态与这种平衡的破坏有关.
- 功能性MRI (fMRI) 缺乏时间分辨率,以在次秒尺度上研究这些动态.
研究的目的:
- 通过使用电皮质谱 (ECoG) 调查胺和普罗波福尔麻醉对大脑动态的影响.
- 在生理学上相关的时间尺度上量化整合/分离平衡的变化.
- 为了比较药物诱导的全球与本地大脑同步的改变.
主要方法:
- 在子 (Macaca fuscata) 模型中使用电皮质谱 (ECoG).
- 分析了作为振荡器处理的ECoG通道的带特定同步.
- 在麻醉下,整合 (远程同步) 与分离 (局部同步) 的量化变化.
主要成果:
- 胺和普罗波麻醉都导致了跨多个频段的长距离大脑整合的显著损失.
- 这种整合损失在贝塔 (13-30 Hz) 和低马 (30-80 Hz) 频段中最为明显.
- 在空间聚类的大脑区域内的局部同步在两种麻醉剂下基本保持不变.
结论:
- 麻醉严重改变大脑动态,损害全球整合,同时保持本地处理.
- ECoG提供了至关重要的次秒时间分辨率,以表征这些动态的意识转变.
- 研究结果强调了整合/分离平衡对于维持正常清醒意识的重要性.
更多相关视频
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
13.7K
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
2.2K
相关概念视频
Stages of General Anesthesia
451
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
451
General Anesthesia: Overview
220
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
220
Parenteral Anesthetics: Overview
129
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
129
Inhalational Anesthetics: Overview
299
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
299
Local Anesthetics: Clinical Application as Spinal Anesthesia
636
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
636
Subconsciousness and No Awareness
244
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
244
