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长期脱水对龙驼 (Camelus dromedarius) 的压力标志物,血液参数和组织形态的影响

Mahmoud A Ali¹, Hassan Abu Damir¹, Muna A Adem¹

¹Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

Frontiers in veterinary science

|December 20, 2023

概括

大象驼通过增加压力激素和抗氧化剂来对抗脱水,同时调节脂肪代谢基因以求生存. 补水很快恢复了生理平衡,显示出了对干旱环境的显著适应性.

科学领域:

生理学生理学生理学
动物科学动物科学
生物化学生物化学

背景情况:

大象驼表现出显著的脱水耐受性,但适应机制仍然不清楚.
增加体温是一种已知的策略,可以减少炎热天气中的蒸发冷却.
一般的压力会对生理功能产生负面影响.

研究的目的:

为了研究脱水和补水对大象驼的压力参数的影响.
了解驼如何减轻脱水压力的生理影响.

主要方法:

19只雄性驼被分为控制,脱水和补水组.
脱水持续了20天,然后在一组人群中进行了72小时的补水.
分析包括血液和组织中的生物化学,血液学,组织病理学和基因表达.

主要成果:

脱水导致体重减轻,食欲下降,压力激素发生变化 (皮质醇,北上腺素,多巴胺增加;上腺素,血清素减少).
增加的氧化应激标志物 (甲) 被增加的抗氧化剂所抵消.
基因表达分析显示,脂肪代谢增加了能量生产和减少支出,这对生存至关重要.

结论:

驼对脱水和厌食症具有强大的适应能力,包括增强的抗压力机制和调节脂肪代谢基因.
补水有效地使生理参数恢复到正常水平.
观察到器官的轻微退行性变化,但驼整体生理学显示出弹性.

关键词:

抗氧化剂维生素维生素脱水 / 补水脱水 / 补水诊断酵素诊断酶这些驼驼驼驼驼驼驼驼驼驼驼驼氧化应激是一种氧化应激.生殖荷尔蒙生殖荷尔蒙压力激素/甲基荷兰胺

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