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一些药物的可溶性,在水溶液的胆化基深度修养溶剂系统:实验数据,建模,和影响的溶液pH值
Samira Zadali Asghar1, Raha Kaviani2, Ali Shayanfar3,4
1Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Iranian journal of pharmaceutical research : IJPR
|December 20, 2023
概括
深度浸泡溶剂 (DES),特别是胆化-糖/尿素 (ChCl-G/U),显著提高药物的水溶性. 定量结构-性质关系 (QSPR) 模型将药物结构与改善的溶解度相关联.
科学领域:
- 制药科学 制药科学
- 绿色化学 绿色化学
- 物理化学 物理化学
背景情况:
- 深度浸泡溶剂 (DES) 正在成为药物应用中有效和环保的溶剂.
- 胆化-甘/尿素 (ChCl-G/U) 系统代表了一种具有药物溶解潜力的新型DES类.
- 提高药物溶解度对于有效的药物输送和配方至关重要.
研究的目的:
- 为了研究各种药物的可溶性在水性ChCl-G/U混合物中.
- 阐明这些DESs的药物溶解的基础机制.
- 开发定量结构属性关系 (QSPR) 模型来预测药物溶解度.
主要方法:
- 使用摇法测量13种药物的可溶性,其重量分数不同 (分别为10%和50%).
- 应用多重线性回归来建立QSPR模型,将药物结构与溶解度相关联.
- 分析溶液pH值作为影响溶解的潜在因素.
主要成果:
- 通过将ChCl-G/U添加到水溶液中,观察到药物溶解度的显著增加.
- 开发的QSPR模型成功地将药物的结构描述符与它们的溶解率联系起来.
- 确定了溶液pH值作为影响ChCl-G/U系统溶解效率的关键参数.
结论:
- 胆化物-甘/尿素 (ChCl-G/U) 系统有效地提高了难以溶解药物的水溶性.
- 在ChCl-G/U+水混合物中的药物溶解性是根据药物的结构性质可预测的.
- 仔细考虑最终溶液的pH值对于使用ChCl-G/U系统优化药物溶解是必不可少的.
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