手握力是否与帕金森病有关? 对71,702名老年人的长度研究
Rochelle Mey1,2, Joaquín Calatayud1,2, José Casaña1
1Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain.
Neurorehabilitation and neural repair
|December 20, 2023
概括
较低的握力与老年人患帕金森病 (PD) 的风险更高有关. 这项研究强调了手握强度作为PD风险评估的潜在查工具.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 没有先前的纵向研究研究了手握强度和帕金森病 (PD) 发病率之间的剂量反应关系.
- 评估PD风险的可修改因素对于早期干预策略至关重要.
研究的目的:
- 调查手握强度与PD发展之间的纵向关联.
- 在一个大型的,代表性的欧洲老年人群中分析这种关联.
主要方法:
- 利用了来自欧洲健康,老龄化和退休调查 (SHARE) 的8个波段的数据.
- 包括来自27个欧洲国家和以色列50岁以上的超过71,000名参与者.
- 采用考克斯回归和受限立方线来建模时间变化的暴露和共变量.
主要成果:
- 在5.0年的中位数随访期间,共确定了314起PD病例.
- 较低的手握强度与明显更高的PD风险相关 (HR:最低三分之一为2.50).
- 剂量反应分析揭示了减少PD风险的性别特异性值,男性和女性的kg值不同.
结论:
- 手握强度是一个有价值的预后指标,用于识别患PD风险的老年人.
- 将手握强度测量纳入查方案可以帮助早期的PD风险分层.
- 进一步的研究可能会完善手握强度在PD查和预防工作中的使用.
相关概念视频
01:15Parkinson's Disease: Overview
554
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
554
01:24Parkinson's Disease: Treatment
274
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
274