人体前列腺组织中的内分泌干扰物和雌激素
J Vitku1, T Skodova, A Varausova
1Institute of Endocrinology, Prague, Czech Republic. jvitku@endo.cz.
Physiological research
|December 20, 2023
概括
这项研究开发了一种新方法来检测前列腺组织中的内分泌干扰物 (ED) 和激素. 经常发现propylparaben和methylparaben,突出显示了潜在的ED对前列腺健康的影响.
科学领域:
- 环境科学 环境科学
- 内分泌学 在内分泌学.
- 分析化学 分析化学
背景情况:
- 内分泌干扰剂 (EDs) 是干扰激素系统的环境化学物质.
- 勃起障碍可能通过雌激素或抗雄激素作用对生殖系统和前列腺产生不利影响.
- 与类固醇一起的前列腺内ED水平对于了解前列腺健康非常重要.
研究的目的:
- 开发和验证一种用于量化前列腺组织中雌激素,ED和植物雌激素的方法.
- 分析这些化合物的未结合和结合形式.
- 在人类前列腺样本中调查这些物质的存在和水平.
主要方法:
- 液体染色学-双重质谱法 (LC-MS/MS) 用于分析.
- 该方法量化了20种化合物,包括雌激素,双,类,氧,非,和植物雌激素.
- 量化的下限 (LLOQs) 范围为0.0172.86 pg/mg的组织.
主要成果:
- 在前列腺组织中经常检测到甲,甲甲,乙甲,双甲 (BPA) 和氧.
- 甲在100%的组织中被发现 (结合和未结合).
- 雌结合物 (E3C) 是检测到的最丰富的雌激素;EDs和植物雌激素首次在前列腺组织中被检测到.
结论:
- 这项研究首次在人类前列腺组织中检测到ED,植物性雌激素和雌结合物.
- 经常检测到像甲这样的特定ED,因此需要进一步调查它们在前列腺健康中的作用.
- 前列腺内的雌激素代谢需要进一步的探索,特别是关于E3C的丰富性.
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